Water → HCID 46836603, compound

Participants

Reaction Steps

100 mg (0.21 mmol) of 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-1,6-dihydropyridazin-3-yl)benzonitrile are dissolved in 3 ml of DMF, 204 mg (0.63 mmol) of caesium carbonate and 16 μl (0.21 mmol) of bromoethane are added. The reaction mixture is stirred at room temperature for 15 h, a further 16 μl (0.21 mmol) of bromoethane are added, and the mixture is stirred at room temperature for a further 24 h. Water is added to the reaction mixture, which is then extracted with dichloromethane, dried and evaporated. The crude mixture is purified by means of preparative HPLC.

Provenance & Evidence