反应详情

温度

60 °C

To a solution of 2-(2,6-dichloro-phenyl)-N-(4,6-dichloro-pyrimidin-5-yl)-acetamide (183 mg, 0.52 mmol) in CH3CN (3 mL) was added Cs2CO3 (342 mg, 1.1 mmol). The resulting mixture was heated to 60° C. in a sealed tube. After 2 h, the reaction mixture was cooled and concentrated. The residue was purified by FCC to afford a colorless solid (100 mg, 61%). MS (ESI): mass calcd. for C12H6Cl3N3O, 312.9; m/z found, 313.9 [M+H]+. 1H NMR (CD3OD): 8.69 (s, 1H), 7.43 (d, J=8.0 Hz, 2H), 7.33-7.28 (m, 1H), 4.72 (s, 2H).

1. temperaturethe reaction mixture was cooled
2. concentrationconcentrated
3. customThe residue was purified by FCC