HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Ethyl 2-(5-chloro-2-methylbenzoyl)-3-(dimethylamino)acrylate | HCID 66677099 | — |
| Product | ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate | HCID 66677632 | 100% |
Reaction Steps
A solution of ethyl 2-(5-chloro-2-methylbenzoyl)-3-(dimethylamino)acrylate (2.87 g, 9.70 mmol) and hydrazine (0.50 mL, 16.0 mmol, 1.6 equiv) in 30 mL ethanol was heated at 70° C. for 2 hours. Solvent and excess hydrazine were then evaporated to provide 2.57 g (100%) of ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate, which was used without further purification. LCMS (ESI) m+H=265.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637526B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-5ff200cee25c43c297391cb3c8ff29dc |
| Source note | uspto-grants-2014_01 |