反应详情

A suspension of 2-amino-6-(4-fluorophenyl)-pyrido(3,2-d)pyrimidin-4(3H)one (2.56 g) and phosphorus pentasulfide (2.5 g) in pyridine (200 ml) was refluxed for 4 hours. The reaction mixture was cooled down and the precipitate was filtered off, thus providing 2.0 g (yield: 73%) of the pure title compound, which was characterized by its mass spectrum as follows: MS (m/z): 273 ([M+H]+, 100).

1. temperaturewas refluxed for 4 hours
2. temperatureThe reaction mixture was cooled down
3. filtrationthe precipitate was filtered off