2-Methoxyethanol → HCID 24958014, compound

HRID 474374Notes

Reaction equation

HRID 474374 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH2:23])[N:14]=[C:15]([O:18][CH2:19][CH2:20][O:21][CH3:22])[C:16]=3[N:17]=2)=[CH:4][CH:3]=1.[CH3:24]OCCO>>[NH2:23][C:13]1[N:14]=[C:15]([O:18][C@@H:19]2[CH2:24][CH2:22][O:21][CH2:20]2)[C:16]2[N:17]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH:9]=[CH:10][C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 59199210HCID 59199210, compound

Product 1

HCID 24958014HCID 24958014, compound

Procedure

6-(4-fluoro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine (example 23) was obtained from 2-methoxy-ethanol; MS (m/z): 315 ([M+H]+, 100).

Sources & evidence

ORD record
ord-6cd0921206224d87ace406db9b91af68
Source dataset
uspto-grants-2014_01
Patent number
US08637531B2

Reaction notes

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