Hydrochloric Acid → HCID 66763381, compound

Participants

Reaction Steps

To a solution of crude {3-[1-(8-Carbamoyl-quinazolin-4-ylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester in methanol (20 ml) was added methanolic hydrogen chloride (22.46 ml; 4.00 M; 89.83 mmol; 10.00 eq.). Stirred overnight and the resulting solid was filtered to obtain 2.0 g of the title product in 64% overall yield MS (M+1) 307

Provenance & Evidence