Phosphorus oxychloride → Methyl 4-{[3-(trifluoromethyl)benzyl]amino}quinazoline-8-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate (150 mg, 0.73 mmol) in 4 mL of anhydrous DCE, POCl3 (80 μL, 0.87 mmol, 1.2 equiv.) was added followed by DIPEA (630 μL, 3.6 mmol, 5.0 equiv.). The resulting mixture was stirred at 90° C. for 1-2 h. After cooling down to rt, 3-(trifluoromethyl)benzylamine (97 μL, 0.81 mmol, 1.1 equiv.) was added. The reaction mixture was stirred at 80° C. for 2-4-h. After work-up, the crude was purified by chromatography to yield the title compound in 66% yield. 1HNMR (in CDCl3): 3.19 (s, 3H), 4.90 (s, 2H), 7.41-7.45 (m, 2H), 7.53 (t, J=8.9 Hz, 2H), 7.58 (s, 1H), 7.97 (dd, J=1.5 and 8.4 Hz, 1H), 8.04 (dd, J=1.5 and 7.3 Hz, 1H). Mass: M+H+: 362.

Provenance & Evidence