4-{[4-Chloro-3-(trifluoromethyl)benzyl]amino}-6-nitroquinazoline-8-carboxamide → 6-Amino-4-{[4-chloro-3-(trifluoromethyl)benzyl]amino}quinazoline-8-carboxamide

Participants

Reaction Conditions

Reaction Steps

Zinc powder (115 mg, 1.76 mmol, 5.0 equiv.) was added to a suspension of 4-{[4-chloro-3-(trifluoromethyl)benzyl]amino}-6-nitroquinazoline-8-carboxamide (150 mg, 0.35 mmol, 1.0 equiv.) in acetic acid (12 mL). The resulting mixture was stirred at 80° C. for 10 min. The reaction mixture was filtered. The filtrate was concentrated and purified by pre-HPLC to yield the title compound as yellow solid in 68% yield. Mass: M+H+: 396.

Provenance & Evidence