HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide → 4-{[(1R)-1-(3-aminophenyl)ethyl]amino}quinazoline-8-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide | HCID 66762984 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{[(1R)-1-(3-aminophenyl)ethyl]amino}quinazoline-8-carboxamide | HCID 66762892 | 93% |
Reaction Steps
A suspension of 4-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide (1.50 g, 4.45 mmol) in methanol (125 mL) was shaken for 3 h in a Parr vessel under 35 psi hydrogen pressure in the presence of 30 wt % palladium on carbon (600 mg). The material was filtered through Celite, concentrated to get the title compound in 93% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637532B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-6ca5de5118e649ec82ce964a5db94f01 |
| Source note | uspto-grants-2014_01 |