Methanol → HCID 66764016, compound

HRID 474451Notes

Reaction equation

HRID 474451 reaction equation
[NH2:1][CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].S(Cl)(Cl)=O.[CH3:21]O>>[CH3:21][O:6][C:5](=[O:7])[CH2:4][CH2:3][CH:2]([NH2:1])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 66763637HCID 66763637, compound

Product 1

HCID 66764016HCID 66764016, compound

Procedure

680 mg (2.49 mmol) 4-Amino-4-(3-nitro-phenyl)-butyric acid were suspended in 5 ml methanol and 635 μl (8.75 mmol) thionyl chloride were added. The mixture was stirred at room temperature overnight. The reaction mixture was evaporated to dryness, methanol was added and again evaporated to dryness.

Workup

  1. customThe reaction mixture was evaporated to dryness, methanol
  2. additionwas added
  3. customagain evaporated to dryness

Sources & evidence

ORD record
ord-b340e8208f1c4c81a58d54585a364606
Source dataset
uspto-grants-2014_01
Patent number
US08637532B2

Reaction notes

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