Ethyl 2-chlorooxazole-4-carboxylate → 2-{3-[(8-Carbamoyl-quinazolin-4-ylamino)-methyl]-phenylamino}-oxazole-4-carboxylic acid ethyl ester
Reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.[CH2:24]([O:26][C:27]([C:29]1[N:30]=[C:31](Cl)[O:32][CH:33]=1)=[O:28])[CH3:25]>>[CH2:24]([O:26][C:27]([C:29]1[N:30]=[C:31]([NH:2][C:3]2[CH:23]=[CH:22][CH:21]=[C:5]([CH2:6][NH:7][C:8]3[C:17]4[C:12](=[C:13]([C:18](=[O:19])[NH2:20])[CH:14]=[CH:15][CH:16]=4)[N:11]=[CH:10][N:9]=3)[CH:4]=2)[O:32][CH:33]=1)=[O:28])[CH3:25]Participants
3
Procedure
The title compound was prepared according to Example 684 starting 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 2-Chloro-oxazole-4-carboxylic acid ethyl ester at 120° C.:
Sources & evidence
- ORD record
- ord-4034bc2fe62942e580e52f04a64a0e0c
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08637532B2
Reaction notes
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