2-Chloro-6-methoxybenzothiazole → 4-[3-(6-Methoxy-benzothiazol-2-ylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

HRID 474461Notes

Reaction equation

HRID 474461 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Cl[C:25]1[S:26][C:27]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:28]=2[N:29]=1>>[CH3:35][O:34][C:32]1[CH:31]=[CH:30][C:28]2[N:29]=[C:25]([NH:2][C:3]3[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=3)[CH2:6][NH:7][C:8]3[C:17]4[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=4)[N:11]=[CH:10][N:9]=3)[S:26][C:27]=2[CH:33]=1

Participants

3

Reactant 2

HCID 2731322-Chloro-6-methoxybenzothiazoleHCID 667633584-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride

Product 1

HCID 770143984-[3-(6-Methoxy-benzothiazol-2-ylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

Procedure

The title compound was prepared according to Example 684 starting 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 2-Chloro-6-methoxy-benzothiazole:

Sources & evidence

ORD record
ord-5aee7169305040e6abefafa2a4202a5a
Source dataset
uspto-grants-2014_01
Patent number
US08637532B2

Reaction notes

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