2-Chloropyridine → HCID 66763805, compound

HRID 474467Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:16][C:17]2[C:26]3[C:21](=[C:22]([C:27]([NH2:29])=[O:28])[CH:23]=[CH:24][CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:5]=[CH:6][CH:7]=1.Cl[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1>>[N:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[NH:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:16][C:17]2[C:26]3[C:21](=[C:22]([C:27]([NH2:29])=[O:28])[CH:23]=[CH:24][CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 79772-Chloropyridine

HCID 66763422HCID 66763422, compound

Product 1

HCID 66763805HCID 66763805, compound

Procedure

The title compound was prepared according to Example 549 starting with 4-[1-(3-Amino-phenyl)-3-pyrrolidin-1-yl-propylamino]-quinazoline-8-carboxylic acid amide and 2-chloro-pyridine. LCMS [468.1 (M+1)].

Sources & evidence

ORD record: ord-3dc6087a27d6418987a8371e6040c127
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08637532B2

Reaction notes

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