HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474471Generated: October 25, 2026
4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride → HCID 178513604, compound
https://huagongshe.com/reaction/474471
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride | HCID 66763358 | — |
| Reactant | HCID 178506089 | HCID 178506089 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178513604 | HCID 178513604 | — |
Reaction Steps
33 mg (0.11 mmol) 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 24 mg (0.11 mmol) 2-Chloro-5-trifluoromethyl-1H-benzoimidazole were dissolved in 500 μl DMF and stirred at 100° C. for 15 h. The reaction mixture was directly purified using preparative HPLC. The product was treated with HCl in methanol and concentrated in the SpeedVac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637532B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-b73afaaeb5fb4c2298486c853c8e7c6f |
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| Source note | uspto-grants-2014_01 |
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