HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-phenyl-4-[(3S)-piperidin-3-ylamino]quinazoline-8-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (3S)-3-{[8-(aminocarbonyl)-6-phenylquinazolin-4-yl]amino}piperidine-1-carboxylate | HCID 66763488 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-phenyl-4-[(3S)-piperidin-3-ylamino]quinazoline-8-carboxamide | HCID 66763009 | — |
Reaction Steps
Dissolved tert-butyl (3S)-3-{[8-(aminocarbonyl)-6-phenylquinazolin-4-yl]amino}piperidine-1-carboxylate (30.00 mg; 0.07 mmol; 1.00 eq.) in methanol (3.00 ml) and then added hydrogen chloride (2.00 ml) (2.0 M in diethyl ether) with stirring. Stirred reaction at room temperature for 18 hours. LCMS: M+1=348 major peak.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637532B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-007daa006f3341c1931e2b142a4798f5 |
| Source note | uspto-grants-2014_01 |