HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzoic Acid → N-(3-cyanophenyl)-4-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzoic Acid | HCID 7478 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 3-Aminobenzonitrile | HCID 16702 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3-cyanophenyl)-4-methoxybenzamide | HCID 904414 | — |
Reaction Steps
5.0 g (33 mmol) 4-methoxybenzoic acid were dissolved in 50 ml DMF. 12.8 g (66 mmol) EDCl, 9.2 g (66 mmol) HOBt and 14.8 ml (132 mmol) 4-methylmorpholine were added and the mixture was stirred for 15 min. Subsequently, 3.9 g (33 mmol) 3-aminobenzonitrile were added and the mixture was stirred for 48 h at room temperature and 6 h at 80° C. The reaction mixture was poured in 500 ml water and the precipitate was filtered, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637532B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-1bd2a35e59fc4454a584fd074e231b46 |
| Source note | uspto-grants-2014_01 |