Potassium Carbonate → HCID 178494122, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	(Z)-methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate	HCID 67773579	—
Reactant	3-(3-Bromo-4-fluorophenyl)propanimidamide	HCID 67773867	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	HCID 178494122	HCID 178494122	42.8%

Reaction Conditions

Temperature	130 °C

Reaction Steps

The mixture of 3-(3-bromo-4-fluorophenyl)propanimidamide (3.28 g, 13.38 mmol), methyl (2Z)-3-hydroxy-2-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-propenoate (1.5 g, 6.69 mmol) and K2CO3 (2.77 g, 20.07 mmol) in NMP (20 mL) was heated with a microwave reactor at 130° C. for 2 h. The mixture was purified with a reverse phase Biotage to provide the title compound (1.2 g, 40.6% yield). LCMS: rt=2.52 min, [M+H+]=419

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637536B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-90c89de6ab1a484f941d22a1f286063b
Source note	uspto-grants-2014_01