HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474564Generated: October 29, 2026
(2E)-3-(4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)-2-propenenitrile → 3-(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)propanenitrile
https://huagongshe.com/reaction/474564
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (2E)-3-(4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)-2-propenenitrile | HCID 67775163 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)propanenitrile | HCID 67773517 | 82.8% |
Reaction Steps
The mixture of (2E)-3-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)-2-propenenitrile (18.0 g, 55.6 mmol) and Pd/C (2.00 g, 1.88 mmol) in THF (150 mL) was stirred at 25° C. under H2 overnight, filtered through a pad of Celite, and concentrated. Purification via a column chromatography afforded the title compound as a white solid (15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-dec8c88b8c4744af8012e3027974ecd7 |
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| Source note | uspto-grants-2014_01 |
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