反应详情

温度

70 °C

To the solution of N-nitroguanidine (912 mg, 8.76 mmol) in ethanol (50.0 mL) was added methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate (858 mg, 4.38 mmol). It was stirred at 70° C. overnight. After removing the solvent, 10 mL water was added. Then HCl(conc) was added to adjust pH ˜3, and the solution was stirred at 0° C. for 1 h. The solid was collected after filtration. It was dried overnight at 50° C. to get the title compound as an off-white solid (674 mg, 61.5% yield). LCMS: rt=1.17 min, [M+H+]=251.1

1. customAfter removing the solvent, 10 mL water
2. additionwas added
3. additionThen HCl(conc) was added
4. stirringthe solution was stirred at 0° C. for 1 h
5. customThe solid was collected
6. filtrationafter filtration
7. customIt was dried overnight at 50° C.