Diisopropylethylamine → N-[2-(4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine

Participants

Reaction Steps

To a solution of 2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)-N-methylethanamine (300 mg, 0.910 mmol) and DIPEA (0.477 mL, 2.73 mmol) in DMF (5 mL) was added 1H-pyrazole-1-carboximidamide (150 mg, 1.365 mmol). The reaction mixture was stirred at room temperature overnight. Purification via a reverse phase Biotage then afforded the title compound (315 mg, 93% yield) as a white powder. LCMS: rt=2.88 min, [M+H+]=371.9

Provenance & Evidence