Trifluoroacetic acid → 2-(4-{[3-(Trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate triflate

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-(3-(trifluoromethyl)phenoxy)phenyl)ethanol (1.395 g, 4.94 mmol) and cyanamide (0.249 g, 5.93 mmol) in THF (15 mL) was added triflic acid (0.527 mL, 5.93 mmol) under argon. The mixture was heated at 55° C. for 3 h. The mixture was purified by a reverse phase biotage with TFA affording the title compound (1.4 g, 59.8% yield). LCMS: rt=1.23 min, [M+H+]=325

Provenance & Evidence