反应详情

To a solution of 4-(4-fluorophenoxy)benzaldehyde (10 g, 46.3 mmol) in methanol (50 mL) was added NaBH4 (1.750 g, 46.3 mmol) portionwise, after addition the mixture was stirred at room temperature overnight. After removing the solvent, the residue was diluted with DCM (50 mL), the suspension was filtered though a pad of Celite, the filtrate was concentrated to afford the title compound (7 g, 30.5 mmol, 65.9% yield) as a gray solid. LCMS: rt=1.49 min, [M+H+]=219

1. additionafter addition the mixture
2. customAfter removing the solvent
3. additionthe residue was diluted with DCM (50 mL)
4. filtrationthe suspension was filtered though a pad of Celite
5. concentrationthe filtrate was concentrated