反应详情

To a solution of 4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde (21 g, 69.8 mmol) in methanol (200 mL) was added slowly NaBH4 (2.64 g, 69.8 mmol) portionwise. The mixture was stirred at room temperature overnight. After removing the solvent, the residue diluted with DCM. The resulting suspension was filtered, the filtrate was concentrated in vacuo to afford the title compound (17.6 g, 55.2 mmol, 79% yield) as yellow solid. LCMS: rt=1.71 min, [M+H+]=303, 305

1. customAfter removing the solvent
2. additionthe residue diluted with DCM
3. filtrationThe resulting suspension was filtered
4. concentrationthe filtrate was concentrated in vacuo