Sodium borohydride → (3-(Trifluoromethyl)-4-(3-(trifluoromethyl)phenoxy)phenyl)methanol

Participants

Reaction Steps

To a solution of 3-(trifluoromethyl)-4-{[3-(trifluoromethyl)phenyl]oxy}benzaldehyde (400 mg, 1.197 mmol) in methanol (10 mL) was added sodium borohydride (47.5 mg, 1.257 mmol) at 0° C. The mixture was stirred at room temperature for 15 min. The result mixture was quenched by acetone, concentrated, and purified via flash chromatography to afford the title compound (350 mg, 0.989 mmol, 83% yield).

Provenance & Evidence