Imidazole → 4-Chloro-3-(trifluoromethyl)phenyl 4-(2-iodoethyl)phenyl ether

Participants

Reaction Conditions

Reaction Steps

To the solution of 2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethanol (80 mg, 0.253 mmol) in DCM (2.5 ml), was added Ph3P (133 mg, 0.505 mmol), imidazole (34.4 mg, 0.505 mmol) and iodide (128 mg, 0.505 mmol) at 0° C., The mixture was stirred at 0° C. for 10 min, then at room temperature for 1 h. The reaction was quenched with sat. Na2SO3 solution. The aqueous phase was extracted with DCM. The combined organic phase was washed with brine, dried over Na2SO4, concentrated and purified via flash chromatography to afford the title compound (50 mg, 46.4% yield) as colorless oil. LCMS: rt=4.47 min

Provenance & Evidence