Nitrobenzene → 2-(Trifluoromethyl)pyrimidin-5-ol

Temperature

90 °C

A mixture of 2-(trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol (6.50 g, 38.7 mmol) and nitrobenzene (30 mL) was heated to 90° C. to form a homogeneous solution. At this temperature, a solution of sodium methoxide (8.5 g, 157 mmol) in methanol (30 mL) was added portionwise, allowing the methanol to distill off before next addition (the whole process took about 3 h). Then the reaction mixture was heated to 120° C. for 1 h. The reaction mixture was cooled to room temperature, and then partitioned between ethyl acetate and water. The organic phase was separated off. The aqueous phase adjusted to pH 4.0 with 6M aqueous HCl and then extracted with EA. The organic phase was dried over sodium sulfate, and filtered. Concentrated in vacuo then afforded the title compound (533 mg, 3.25 mmol, 8.4% yield). LCMS: rt=1.78 min, [M+H+]=165

1. customto form a homogeneous solution
2. distillationto distill off before next addition (the whole process
3. temperatureThen the reaction mixture was heated to 120° C. for 1 h
4. temperatureThe reaction mixture was cooled to room temperature
5. custompartitioned between ethyl acetate and water
6. customThe organic phase was separated off
7. extractionextracted with EA
8. dry with materialThe organic phase was dried over sodium sulfate
9. filtrationfiltered
10. concentrationConcentrated in vacuo

ORD record

ord-dcc2c015b86f455d9cabd5504f97df17

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08637536B2