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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474798Generated: October 30, 2026

Potassium Acetate → HCID 178494124, compound

https://huagongshe.com/reaction/474798

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium AcetateHCID 517044—
ReactantMethyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylateHCID 67773588—
Reactant3-(4-(3-(Trifluoromethyl)phenoxy)phenyl)propanimidamideHCID 67773885—
SolventTolueneHCID 1140—
ProductHCID 178494124HCID 17849412464.3%

Reaction Steps

The same procedure as E38 from a mixture of 3-(4-(3-(trifluoromethyl) phenoxy)phenyl)propanimidamide (200 mg, 0.580 mmol), methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate (130 mg, 0.580 mmol) and potassium acetate (171 mg, 1.740 mmol) in toluene (10 mL) to afford the title compound (180 mg, 61.1% yield) as a yellow solid. LCMS: rt=8.88 min, [M+H+]=483.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08637536B2
Source datasetuspto-grants-2014_01
ORD IDord-d5902071cc3f416180dab06f671783f5
Source noteuspto-grants-2014_01