HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Acetate → HCID 178494124, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | Methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate | HCID 67773588 | — |
| Reactant | 3-(4-(3-(Trifluoromethyl)phenoxy)phenyl)propanimidamide | HCID 67773885 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178494124 | HCID 178494124 | 64.3% |
Reaction Steps
The same procedure as E38 from a mixture of 3-(4-(3-(trifluoromethyl) phenoxy)phenyl)propanimidamide (200 mg, 0.580 mmol), methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate (130 mg, 0.580 mmol) and potassium acetate (171 mg, 1.740 mmol) in toluene (10 mL) to afford the title compound (180 mg, 61.1% yield) as a yellow solid. LCMS: rt=8.88 min, [M+H+]=483.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637536B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-d5902071cc3f416180dab06f671783f5 |
| Source note | uspto-grants-2014_01 |