HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474802Generated: October 25, 2026
Diisopropylethylamine → HCID 178518543, compound
https://huagongshe.com/reaction/474802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(Pyrimid-5-ylmethyl)-2-thiouracil | HCID 10966039 | — |
| Reactant | 4-(Chloromethyl)phenyl 4-chloro-3-(trifluoromethyl)phenyl ether | HCID 66825537 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178518543 | HCID 178518543 | 26.7% |
Reaction Steps
To a suspension of 5-(5-pyrimidinylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (75 mg, 0.343 mmol) and DIPEA (0.163 ml, 0.934 mmol) in DCM (2 mL) was added 1-chloro-4-{[4-(chloromethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (100 mg, 0.311 mmol). The solution was heated at 60° C. overnight. Purification via MDAP then afforded the title compound (42 mg, 26.7% yield). LCMS: rt=3.49 min, [M+H+]=505
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-2547ab57502b4bbd83c0aea18a6aadcc |
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| Source note | uspto-grants-2014_01 |
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