反应详情

A mixture of 1-chloro-4-{[4-(chloromethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (65 mg, 0.202 mmol), 5-ethyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (47.4 mg, 0.304 mmol) and DIPEA (0.163 mL, 0.933 mmol) in DCE (3.0 mL) was sealed in a vessel and stirred at room temperature for 5 min, then was heated with a microwave condition at 80° C. for 30 min. After cooling, the reaction was quenched with water, extracted with EA, the combined organic layers were dried with sodium sulfate, concentrated, and purified via MDAP to afford the title compound (41 mg, 45.9% yield). LCMS: rt=3.94 min, [M+H+]=441

1. customwas sealed in a vessel
2. temperaturewas heated with a microwave condition at 80° C. for 30 min
3. temperatureAfter cooling
4. customthe reaction was quenched with water
5. extractionextracted with EA
6. dry with materialthe combined organic layers were dried with sodium sulfate
7. concentrationconcentrated
8. custompurified via MDAP