HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474807Generated: October 26, 2026
Potassium Carbonate → HCID 178518544, compound
https://huagongshe.com/reaction/474807
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Chloromethyl)phenyl 4-chloro-3-(trifluoromethyl)phenyl ether | HCID 66825537 | — |
| Reactant | HCID 86666220 | HCID 86666220 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178518544 | HCID 178518544 | 8.9% |
Reaction Steps
A mixture of 1-chloro-4-(4-(chloromethyl)phenoxy)-2-(trifluoromethyl)benzene (200 mg, 0.623 mmol), 5-(1H-indol-1-ylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (160 mg, 0.623 mmol), and K2CO3 (200 mg, 1.447 mmol) in DMF (5 mL) was heated at 80° C. for 3 h. Purification via MDAP then afforded the title compound (30 mg, 8.44% yield). LCMS: rt=4.19 min, [M+H+]=542
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-01e69f81d4734a508d3f057671d806e1 |
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| Source note | uspto-grants-2014_01 |
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