HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474814Generated: October 27, 2026
Diisopropylethylamine → HCID 178510106, compound
https://huagongshe.com/reaction/474814
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(Pyrimid-5-ylmethyl)-2-thiouracil | HCID 10966039 | — |
| Reactant | 2-(4-Chloro-3-(trifluoromethyl)phenoxy)-5-(chloromethyl)benzonitrile | HCID 67773500 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178510106 | HCID 178510106 | 43.2% |
Reaction Steps
To a suspension of 5-(5-pyrimidinylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (35.0 mg, 0.159 mmol) and DIPEA (0.08 mL, 0.458 mmol) in DCM (1 mL) was added 2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(chloromethyl)benzonitrile (50 mg, 0.144 mmol). The solution was heated at 60° C. overnight. Purification via MDAP then afforded the title compound (33 mg, 43.1% yield). LCMS: rt=3.28 min, [M+H+]=531
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-514a7be48c1f4fb49d3715f142a0503c |
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| Source note | uspto-grants-2014_01 |
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