Potassium Carbonate → HCID 178494159, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-(2-Methoxypyrimidin-5-ylmethyl)-2-thiouracil	HCID 21936244	—
Reactant	4-Chloro-3-(trifluoromethyl)phenyl 4-(2-iodoethyl)phenyl ether	HCID 67775359	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 178494159	HCID 178494159	8.55%

Reaction Conditions

Temperature	50 °C

Reaction Steps

A mixture of 1-chloro-4-{[4-(2-iodoethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (400 mg, 0.938 mmol), 5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (258 mg, 1.031 mmol) and K2CO3 (259 mg, 1.875 mmol) in DMF (3 mL) was heated with a microwave reactor at 50° C. for 15 min. Purification via reverse phase flash chromatography then afforded the title compound (44 mg, 0.080 mmol, 8.55% yield). LCMS: rt=3.76 min, [M+H+]=549

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637536B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-a1229713a38747c9bc074d20b03a82e7
Source note	uspto-grants-2014_01