HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474832Generated: October 30, 2026
Potassium Carbonate → HCID 178494148, compound
https://huagongshe.com/reaction/474832
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(4-Fluorophenoxy)phenethyl carbamimidate | HCID 67952534 | — |
| Reactant | Methyl 2-formyl-3-(2-methoxypyrimidin-5-yl)propanoate | HCID 86666188 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178494148 | HCID 178494148 | 18.4% |
Reaction Steps
A mixture of 4-(4-fluorophenoxy)phenethyl carbamimidate (50 mg, 0.182 mmol), methyl 2-formyl-3-[2-(methyloxy)-5-pyrimidinyl]propanoate (49.0 mg, 0.219 mmol) and K2CO3 (101 mg, 0.729 mmol) in NMP (2 mL) was heated with a microwave reactor at 135° C. for 2 h. Purification via MDAP then afforded the title compound (15 mg, 18.35% yield). LCMS: rt=3.14 min, [M+H+]=449
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-1b04beb263f54a789b95a4dde49721f3 |
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| Source note | uspto-grants-2014_01 |
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