HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178426746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-{4-[(3-Chloro-4-methylphenyl)oxy]phenyl}ethyl imidocarbamate | HCID 67774878 | — |
| Reactant | Methyl 2-formyl-3-(pyrimidin-5-yl)propanoate | HCID 86666186 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178426746 | HCID 178426746 | 6.83% |
Reaction Steps
Prepared in a manner similar to that described for E149 using 2-{4-[(3-chloro-4-methylphenyl)oxy]phenyl}ethyl imidocarbamate (150 mg, 0.359 mmol) and methyl 2-formyl-3-(5-pyrimidinyl)propanoate (84 mg, 0.431 mmol) and K2CO3 (198 mg, 1.436 mmol) in NMP (2 ml), to afford the title compound (11 mg, 6.83% yield). LCMS: rt=3.33 min, [M+H+]=449
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637536B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c17c3cc11d004ebaa49e8881db42749c |
| Source note | uspto-grants-2014_01 |