Ethanol → HCID 178494134, compound

Participants

Reaction Conditions

Reaction Steps

2-[4-(4-fluoro-phenoxy)-phenyl]ethylamine (0.204 mmol, 1 eq) and 5-(2-methoxy-pyrimidin-5-ylmethyl)-2-methylsulfanyl-1H-pyrimidin-4-one (0.082 mmol, 0.4 eq) were dissolved in dry ethanol (200 μL) and stirred at 125° C. for 16 hours. Solvent was evaporated and crude product was purified by Waters Mass Direct Autopurification system giving 2-({2-[4-(4-fluoro-phenoxy)phenyl]-ethyl}-methyl-amino)-5-(2-methoxy-pyrimidin-5-ylmethyl)-1H-pyrimidin-4-one (0.039 mmol, yield: 19%, HPLC-MS/UV: [M+H]+=462.24; rt: 10.59 min; purity: 99%). 1H NMR (300 MHz; CDCl3) δ/ppm 2.85 (t, J=7.17, 2H), 2.98 (s, 2H), 3.51 (s, 2H), 3.73 (t, J=6.72, 2H), 3.95 (s, 3H), 6.85-7.05 (m, 5H), 7.11-7.17 (m, 2H), 7.23-7.28 (m, 1H), 7.65 (s, 1H), 8.37 (s, 1H), 10.09 (br.s., 1H)

Provenance & Evidence