Hydrochloric Acid → HCID 66874687, compound

Participants

Reaction Steps

1.25 M HCl in MeOH (48 μL, 0.060 mmol) was added to a solution of 4-((5-fluoropyridin-2-yl)methoxy)-1-(3-isopropyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indol-8-yl)-pyridin-2(1H)-one (27 mg, 0.060 mmol) in MeOH (2.0 mL), and the resulting solution was stirred at ambient temperature for 18 h. The mixture was concentrated to dryness to provide the title compound (26 mg, 90%) as an off-white powder: ESI MS m/z 447 [M+H]+; HPLC (Method A) 97.6% (AUC), tR=12.7 min.

Provenance & Evidence