4-(2,4-dichlorobenzyloxy)pyridin-2(1H)-one → tert-Butyl 8-(4-(2,4-dichlorobenzyloxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-(2,4-dichlorobenzyloxy)pyridin-2(1H)-one	HCID 58092234	—
Reactant	tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate	HCID 66874851	—
Product	tert-Butyl 8-(4-(2,4-dichlorobenzyloxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate	HCID 70805144	45%

Reaction Steps

tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate (155 mg, 0.411 mmol) and 4-(2,4-dichlorobenzyloxy)pyridin-2(1H)-one (110 mg, 0.411 mmol) were reacted following the procedure for Example 2 (step d) to provide the title compound (105 mg, 45%) as a yellow foam: ESI MS m/z 568 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637501B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-a4ef8d95599e4d7b9d89e26f92a7bf3f
Source note	uspto-grants-2014_01