HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one → tert-Butyl 8-(4-(2,4-difluorobenzyloxy)-2-oxopyridin-1 (2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one | HCID 22050390 | — |
| Reactant | tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate | HCID 66874851 | — |
| Product | tert-Butyl 8-(4-(2,4-difluorobenzyloxy)-2-oxopyridin-1 (2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate | HCID 70805146 | 59.2% |
Reaction Steps
tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate (155 mg, 0.411 mmol) and 4-(2,4-difluorobenzyloxy)pyridin-2(1H)-one (97 mg, 0.41 mmol) was reacted following the procedure for Example 2 (step d) to provide the title compound (130 mg, 59%) as a green oil: ESI MS m/z 536 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637501B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-819f26dda125437d97a10b0af4ca3f6d |
| Source note | uspto-grants-2014_01 |