反应详情

温度

130 °C

tert-Butyl 2-bromo-10-methyl-7,8,9,10-tetrahydropyrido[3′,2′:4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate (0.21 g, 0.56 mmol), 4-((5-fluoropyridin-2-yl)methoxy)pyridin-2(1H)-one (0.12 g, 0.56 mmol), and Cs2CO3 (0.12 g, 0.61 mmol) were suspended in DMSO (3.2 mL), and the mixture was degassed under vacuum for 15 min. The system was flushed with Ar, and 8-hydroxyquinoline (24 mg, 0.17 mmol) and copper iodide (0.13 g, 0.67 mmol) were added to the suspension. The evacuation/Ar flushing process was repeated twice more, and the reaction mixture was heated at 130° C. for 18 h under N2. The mixture was cooled, diluted with 5.0:3.5:1.5 NH4Cl (aq.)/NH4OH/H2O (30 mL), and the resulting suspension was stirred at ambient temperature for 30 min. The resulting solids were collected by filtration, dissolved in CH2Cl2 (40 mL) and washed with 5.0:3.5:1.5 NH4C1(aq.)/NH4OH/H2O (2×30 mL). The resulting organic solution was dried over Na2SO4 and filtered. Activated charcoal was added to the filtrate; the resulting suspension was filtered through a celite plug with 80:18:2 CH2Cl2/MeOH/NH4OH; and the filtrate was concentrated to dryness under reduced pressure. Flash chromatography (12 g ISCO column, (1:1 hexanes/EtOAc)/(80:18:2 CH2Cl2/MeOH/NH4OH), 100:0 for 4 column volumes, increased to 50:50 over 20 column volumes and held for 4 column volumes; increased to 0:100 over 10 column volumes) gave the title compound (130 mg, 45%) as an off-white foam: 1H NMR (500 MHz, DMSO-d6) δ 8.62 (d, J=3.0 Hz, 1H), 7.97 (dd, J=7.5, 7.5 Hz, 1H), 7.84-7.80 (m, 2H), 7.67-7.64 (m, 1H), 7.28 (dd, J=8.5, 8.5 Hz, 1H), 6.17 (dd, J=7.5, 2.5 Hz, 1H), 5.98 (d, J=2.5 Hz, 1H), 5.23 (s, 2H), 4.58 (s, 2H), 3.71 (s, 3H), 3.66 (t, J=5.0 Hz, 2H), 3.03 (t, J=6.0 Hz, 2H), 1.94-1.91 (m, 2H), 1.35-1.27 (m, 9H).

1. customthe mixture was degassed under vacuum for 15 min
2. additionwere added to the suspension
3. customThe evacuation/Ar flushing process
4. temperatureThe mixture was cooled
5. additiondiluted with 5.0:3.5:1.5 NH4Cl (aq.)/NH4OH/H2O (30 mL)
6. filtrationThe resulting solids were collected by filtration
7. dissolutiondissolved in CH2Cl2 (40 mL)
8. washwashed with 5.0:3.5:1.5 NH4C1(aq.)/NH4OH/H2O (2×30 mL)
9. dry with materialThe resulting organic solution was dried over Na2SO4
10. filtrationfiltered
11. additionActivated charcoal was added to the filtrate
12. filtrationthe resulting suspension was filtered through a celite plug with 80:18:2 CH2Cl2/MeOH/NH4OH
13. concentrationand the filtrate was concentrated to dryness under reduced pressure
14. temperatureFlash chromatography (12 g ISCO column, (1:1 hexanes/EtOAc)/(80:18:2 CH2Cl2/MeOH/NH4OH), 100:0 for 4 column volumes, increased to 50:50 over 20 column volumes and held for 4 column volumes; increased to 0:100 over 10 column volumes)