4-(4-Fluorophenethyl)piperazin-2-one → tert-Butyl 8-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Fluorophenethyl)piperazin-2-one	HCID 57514761	—
Reactant	tert-butyl 8-bromo-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate	HCID 58093439	—
Product	tert-Butyl 8-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate	HCID 58093443	71.6%

Reaction Steps

tert-Butyl 8-bromo-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate (230 mg, 0.609 mmol) and 4-(4-fluorophenethyl)piperazin-2-one (123 mg, 0.534 mmol) were reacted following the procedure for Example 53 (step b) to provide the title compound (199 mg, 71%) as a colorless oil: ESI MS m/z 521 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637501B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-9e15d30a5ad34aaa93785ceafd204517
Source note	uspto-grants-2014_01