Hydrochloride methanol → 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

HRID 475027Notes

Reaction equation

HRID 475027 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:2].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:35](=[O:36])[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28]2=[O:37])[C:21]1=[O:38].[ClH:39].CO>C(Cl)Cl>[ClH:39].[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:16].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:28](=[O:37])[C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:35]2=[O:36])[C:21]1=[O:38]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 710827862-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate

Product 1

HCID 866187522-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (76 mg) obtained from example 6 was dissolved in DCM (10 mL) and 15% HCl/methanol solution (5 mL) were added dropwise. The solvent was eliminated by rotary evaporation in vacuo and then white solid (82 mg) was obtained.

Workup

  1. customThe solvent was eliminated by rotary evaporation in vacuo

Sources & evidence

ORD record
ord-4b277b77da9e45e3be51998e3000fedf
Source dataset
uspto-grants-2014_01
Patent number
US08637545B2

Reaction notes

Loading…