HRID475027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21893726

Hydrochloride methanol

CH5ClO

结构：CCN(CC)CC(=O)N[C@H](C(=O)O)C(C)C.O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1CCO

HCID71082786

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CC(=O)N[C@H](C(=O)O)C(C)C.Cl.O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1CCO

HCID86618752

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The compound (76 mg) obtained from example 6 was dissolved in DCM (10 mL) and 15% HCl/methanol solution (5 mL) were added dropwise. The solvent was eliminated by rotary evaporation in vacuo and then white solid (82 mg) was obtained.

WORKUP

后处理

customThe solvent was eliminated by rotary evaporation in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b277b77da9e45e3be51998e3000fedf
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08637545B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:2].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:35](=[O:36])[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28]2=[O:37])[C:21]1=[O:38].[ClH:39].CO>C(Cl)Cl>[ClH:39].[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:16].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:28](=[O:37])[C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:35]2=[O:36])[C:21]1=[O:38]