ethyl (E)-3-[5-(hydroxymethyl)pyridin-2-yl]acrylate → Ethyl 3-[5-(Hydroxymethyl)pyridin-2-yl]propanoic acid

HRID 475043Notes

Reaction equation

HRID 475043 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6](/[CH:9]=[CH:10]/[C:11]([O:13]CC)=[O:12])=[N:7][CH:8]=1.[CH3:16][CH:17](CC1C=CC(CO)=CC=1)C(O)=O>>[CH2:16]([CH:10]([CH2:9][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][OH:1])=[CH:8][N:7]=1)[C:11]([OH:13])=[O:12])[CH3:17]

Participants

3

Reactant 2

HCID 59145589ethyl (E)-3-[5-(hydroxymethyl)pyridin-2-yl]acrylateHCID 67022307Methyl 3-[4-(hydroxymethyl)phenyl]propanoic acid

Product 1

HCID 67022359Ethyl 3-[5-(Hydroxymethyl)pyridin-2-yl]propanoic acid

Procedure

The title compound was prepared from Intermediate E by the same methodology used to make Intermediate B.

Sources & evidence

ORD record
ord-8b48a1d0abff470bae843af47d66d76f
Source dataset
uspto-grants-2014_01
Patent number
US08637547B2

Reaction notes

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