HCID 11007944, compound → 1425931-79-8

HRID 475064Notes

Reaction equation

HRID 475064 reaction equation
[F:1][C:2]1(F)[CH2:4][CH:3]1[C:5]1[NH:9][N:8]=[C:7]([NH2:10])[CH:6]=1.F[C@H]1C[C@H]1C(OCC)=O>>[F:1][C@H:2]1[CH2:4][C@H:3]1[C:5]1[NH:9][N:8]=[C:7]([NH2:10])[CH:6]=1

Participants

3

Reactant 2

HCID 11007944HCID 11007944, compoundHCID 67089002HCID 67089002, compound

Product 1

HCID 866898181425931-79-8

Procedure

Racemic cis-5-(2-fluorocyclopropyl)-1H-pyrazol-3-amine (49) was prepared analogously using the procedure as described for 5-(2,2-difluorocyclopropyl)-1H-pyrazol-3-amine, using ethyl cis-2-fluorocyclopropane-1-carboxylate in place of butyl 2,2-difluorocyclopropanecarboxylate as the starting material: 1H NMR (300 MHz, DMSO-d6) δ 5.16 (s, 1H), 4.67-4.95 (m, 1H), 4.50 (br, 2H), 3.40 (br s, 1H), 1.95-1.84 (m, 1H), 1.20-1.12 (m, 2H); MS (ESI+) m/z=142 [M+1]+.

Sources & evidence

ORD record
ord-8f209f56d3a24903a2bb98b420868b54
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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