反应详情

Racemic cis-5-(2-fluorocyclopropyl)-1H-pyrazol-3-amine (49) was prepared analogously using the procedure as described for 5-(2,2-difluorocyclopropyl)-1H-pyrazol-3-amine, using ethyl cis-2-fluorocyclopropane-1-carboxylate in place of butyl 2,2-difluorocyclopropanecarboxylate as the starting material: 1H NMR (300 MHz, DMSO-d6) δ 5.16 (s, 1H), 4.67-4.95 (m, 1H), 4.50 (br, 2H), 3.40 (br s, 1H), 1.95-1.84 (m, 1H), 1.20-1.12 (m, 2H); MS (ESI+) m/z=142 [M+1]+.