Phosphorus tribromide → HCID 86694683, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-amino-1H-pyrazol-5-yl)ethanol (13 g, 102.2 mmol) in DCM (200 mL) was added PBr3 (83 g, 306.7 mmol). The reaction mixture was heated under reflux for 3 h and then cooled to −10° C. and carefully quenched with aq satd Na2CO3 (200 mL). The resulting mixture was extracted with DCM (3×200 mL), and the Na2CO3 (200 mL). The resulting mixture was extracted with DCM (3×200 mL) combined organic layers were washed with brine, dried over anhydrous Na2SO4, and then concentrated in vacuo to give 5-(2-bromoethyl)-1H-pyrazol-3-amine (9.3 g, 48%) as a yellow solid.

Provenance & Evidence