Hydroxyamine hydrochloride → HCID 86694697, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-(6-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)ethanone (1.1 g, 4.3 mmol) and NaOAc (3.5 g, 43 mmol) in MeOH (20 mL) at RT was added hydroxylamine hydrochloride (896 mg, 12.9 mmol). The reaction mixture was stirred at 80° C. for 0.5 h then concentrated in vacuo. Water (200 mL) was added, and the mixture was extracted with EtOAc (50 mL×3), dried (MgSO4), and concentrated in vacuo to afford 1-(6-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)ethanone oxime as a yellow solid (1.1 g, 90.2%). MS (ESI): m/z=194.3 [M+1]+.

Provenance & Evidence