反应详情

A mixture of 3-bromobenzene-1,2-diamine (1.5 g, 8 mmol) in formic acid (10 mL) was heated at reflux for 2 h. The reaction mixture was concentrated in vacuo. To the residue was added a satd. aq. solution of NaHCO3 and mixture was extracted with EtOAc. The combined extracts was dried (MgSO4), filtered, and evaporated in vacuo to afford 4-bromo-1H-benzo[d]imidazole as a gray solid (1.5 g, 95%). MS (ESI): m/z=197 [M+1]+.

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. additionTo the residue was added a satd
5. extractionaq. solution of NaHCO3 and mixture was extracted with EtOAc
6. dry with materialThe combined extracts was dried (MgSO4)
7. filtrationfiltered
8. customevaporated in vacuo