反应详情

To a solution of 6-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile (120 mg, 0.5 mmol) in a solution of NH3/MeOH (7 N, 10 mL) was added Raney nickel (50 mg). The mixture was stirred under hydrogen at RT for 2 hours. It was filtered with Celite, and the filtrate was concentrated in vacuo to afford (6-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine (113) as brown solid (120 mg, ˜100%). MS (ESI): m/z=246.3 [M+1]+.

1. filtrationIt was filtered with Celite
2. concentrationthe filtrate was concentrated in vacuo