3-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile → (3-Methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine

Participants

Reaction Steps

A mixture of 3-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile (140 mg, 0.544 mmol) and Raney nickel (20 mg) in NH3/MeOH (7N, 10 mL) was stirred under hydrogen overnight. The reaction mixture was filtered with Celite® and the filtrate concentrated in vacuo to afford (3-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine as an oil (119) 130 mg, 91.4%). MS (ESI): m/z=262 [M+1]+.

Provenance & Evidence