反应详情

温度

110 °C

A mixture of 3-bromo-5-fluorobenzene-1,2-diamine (10.1 g, 49 mmol) in formic acid (20 mL) was heated at 110° C. overnight. The reaction mixture was concentrated, and to the residue was added MeOH (5 mL) to form a precipitate. The precipitate was filtered and washed with MeOH (2 mL) to afford 4-bromo-6-fluoro-1H-benzo[d]imidazole as a yellow solid (10 g, yield, 73%). MS (ESI): m/z=215 [M+1]+.

1. concentrationThe reaction mixture was concentrated
2. additionto the residue was added MeOH (5 mL)
3. customto form a precipitate
4. filtrationThe precipitate was filtered
5. washwashed with MeOH (2 mL)
6. customto afford