Hydroxyamine hydrochloride → HCID 86694706, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(6-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-4-yl)ethanone (676 mg, 3.8 mmol), NaOAc (3.12 g, 38 mmol), and hydroxylamine hydrochloride (792 mg, 11.4 mmol) in MeOH (60 mL) was heated at 80° C. for 1 h. The reaction mixture was concentrated in vacuo. To the residue was added water (200 mL) and the resulting mixture was extracted with EOAc (50 mL×3). The combined extracts were concentrated in vacuo to afford 1-(6-fluoro-1H-benzo[d]imidazol-4-yl)ethanone oxime as a yellow solid (658 mg, 89.8%). MS (ESI): m/z=194.3 [M+1]+.

Provenance & Evidence